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I’m a member of a number of lists, and always get blasted with Out of Office replies when I post.
There’s a handy-dandy switch introduced in E2k3 that gets rid of this annoyance.

In Exchange 2003, it is now possible to modify the Out Of Office behaviour to help in these situations. A new registry key exists that prevents the sending of Out Of Office responses unless the recipient is explicitly listed in either the TO: or CC: fields of the message. Since mailing list posts aren’t addressed explicitly to list members, the suppression of Out Of Office responses to mailing list members is achieved.

To enable this feature, add the DWORD parameter SuppressOOFsToDistributionLists with a value of 1 into the following registry location:

HKLMSystemCurrentControlSetServicesMSExchangeISParametersSystem

More here.

Alex Eckelberry