My advice? Don’t play around with unsupported hotfixes for something that, based the best data available, is not a significant issue. Keep your AV sigs updated and move on.
And remember that malware authors themselves are interested in market share. We’re increasingly seeing malware authors not even bother to have compatibility with this platform. It’s a real hassle to program low-level code for both NT kernel and Windows 9x. In other words, Windows 9x systems is a waste of time for them. See the OS platform trends here.